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We knew the network was looking for procedurals, and Paul [Attanasio] came up with this medical idea that was like a cop procedural. But I quickly began to realize that we needed that character element. Before she broke into the acting world, House actress Lisa Edelstein, who played Dr. Lisa Cuddy, was infamous in New York’s club scene of the 1980s.
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House realizes that he's going to give Thirteen the drug once again and tells the patient that he'll inject the drug in himself because more drugs would kill Thirteen. The patient doesn't care, noting that since Thirteen has taken everything that he's taken, any bad reactions she has to it would more accurately reflect what would happen to him. Thirteen tells House that she'll either die from the drug or the patient will shoot her, so she'll die either way. Throughout the series, Cuddy struggles to maintain balance between giving House room to operate and staying on the right side of ethics and the law.
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Dr. James Wilson is a direct parallel to Holmes’ partner Dr. John Watson. Rebecca Adler, a patient in the pilot, is named after the main antagonist in the Sherlock Holmes novels. And at the end of season 2, House is shot by a man named Jack Moriarty.
Omar Epps played Dr. Eric Foreman.

She goes to leave, but Benjamin says he will give her the other kidney. She reminds him he will die, but he says he can go on dialysis and save even more lives when he dies and donates his other organs. Thirteen's portrayer, Olivia Wilde, was demoted from the main cast and was made again a recurring character. She only made three but important appearances in this season. The reaction to the hyperbaric chamber seems to rule out carbon monoxide, but Thirteen wants to test the assistant and patient for infections because the assistant seemed to be in a daze.
The softer, gentler House, the one who admitted to vulnerabilities and tried really, really hard to be a grown up, has been buried again in a landslide of recklessness and self-destruction. House might be hell-bent to dig up the dirt on Thirteen, but he recovers some of himself along the way. Taub’s dalliances are a consistent boulder in his own path and his dalliances eventually do lead to divorce, though he and his wife maintain an unconventional kinship.
Dr. Robert Chase
However, despite her faith in House, Wilson pointed out that she is one of the only fellows House has ever had who has not "fallen under his spell". Indeed, House has been particularly inept in manipulating Thirteen (although he did succeed in getting her to return to the team in Teamwork). The team come in the next morning and start going through files. Foreman says he missed a call from House the previous night and wonders if he's in. Thirteen tells her about the parasite, but tells her she's going to be okay. Thirteen tells her she's lashing out, and she knows she saved her life.
Robert Sean Leonard was Dr. James Wilson.
Taub mentioning to Chase about Thirteen having "Sapphic sex". "Sapphic" refers to lesbian/ism, from the Greek lyric poet Sappho who lived on the island of Lesbos. Thirteen is the only currently-known doctor on the show that is not heterosexual; her bisexuality has been explored since the episode Don't Ever Change.
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The team must excavate, catalogue, and analyze what it finds to uncover the psychic cause. And Foreman does some digging of his own, resolved to uncover the secret to Taub’s (Peter Jacobsen) romantic success. As the trailers for “The Dig” reveal, Thirteen has been in jail for six of the last 12 months she’s been missing.

He tells her that he supports her choice to try the new treatment. Chase and Thirteen are discussing the side effects of the drugs they gave Dr. Richardson. Thirteen wants to know if Chase is going to ask her about the Huntington's trial. He says he's not interested, but asks if she wants to have sex with him.
In the Holmes books, the detective’s arch-nemesis is criminal mastermind James Moriarty. Another of the new crew, Dr. Chris Taub (Peter Jacobsen) is a former plastic surgeon turned diagnostician. He is chosen in part for his willingness to stand up to House, a quality Dr. Cuddy favors. Taub enjoyed early success in his career which was stifled by missteps in his personal life. He has a history of cheating on his wife, which cost him his plastic surgery practice and nearly his marriage. An immunology specialist and one of the original trio, Dr. Allison Cameron (Jennifer Morrison) was the heart and soul of the diagnostic department.
Thirteen eventually admits to House that she did what she had to when her brother's time had come, and that now she is alone and will have nobody there for her when her time comes. House later tells her that he is willing to euthanise her when she needs him to and rehires her onto his team. Thirteen draws five full syringes of bloody liquid and manages to restore blood flow to the arm. Chase notes they have no idea what her problem is and there are too many possibilities. However, Thirteen doesn't think it is illegal drugs because her kidneys and heart seem to be fine. Chase thinks it might just be the hepatitis, but Thirteen reminds him if that were the issue, her whole body would be swollen, not just her left arm.
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